The Gene is praised as a sweeping, deeply personal history of heredity that manages to be both scientifically rigorous and emotionally resonant. Bill Bryson quotes Mukherjee directly in The Body, using his observations as framing devices, while David Quammen treats the book as a parallel recent history of heredity that his own evolutionary narrative extends into deep time.
Philipp Dettmer references it for its account of how antibody diversity arises through genetic recombination, illustrating the book's reach across biology. Readers consistently highlight Mukherjee's ability to weave family memoir with cutting-edge science, from Mendel's peas to CRISPR, though some note that the sheer scope of the book means certain topics receive only surface-level treatment.